abstract：:Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid arte...

journal_title：Neurobiology of aging

authors： Menyhárt Á,Makra P,Szepes BÉ,Tóth OM,Hertelendy P,Bari F,Farkas E

更新日期：2015-12-01 00:00:00

abstract：:Arrested autophagy may contribute to the pathogenesis of Alzheimer's disease. Because we found that chloroquine (CQ) causes arrested autophagy but clioquinol (ClioQ), a zinc ionophore, activates autophagic flux, in the present study, we examined whether ClioQ can overcome arrested autophagy induced by CQ or mutant pre...

journal_title：Neurobiology of aging

authors： Seo BR,Lee SJ,Cho KS,Yoon YH,Koh JY

更新日期：2015-12-01 00:00:00

abstract：:Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the impact of GBA mutations on the longitudinal clinical course of PD patients by retrospective cohort design. GBA-coding reg...

journal_title：Neurobiology of aging

authors： Oeda T,Umemura A,Mori Y,Tomita S,Kohsaka M,Park K,Inoue K,Fujimura H,Hasegawa H,Sugiyama H,Sawada H

更新日期：2015-12-01 00:00:00

abstract：:Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer's disease patients and mouse models display age-related or amyloid-β peptide (Aβ)-induced reductions in CD200. The goal of this study was to dete...

journal_title：Neurobiology of aging

authors： Varnum MM,Kiyota T,Ingraham KL,Ikezu S,Ikezu T

更新日期：2015-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common dementia among the elderly that involves complex neurodegenerative alterations. Multiple cellular processes including regulation of amyloid-β peptide, tau, inflammation, and cell death have been suggested to associate with AD, but it remains largely unknown if long noncoding...

journal_title：Neurobiology of aging

authors： Zhou X,Xu J

更新日期：2015-11-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer's disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel single nucleotide polymorphisms (SNPs)-to-genes approach and functional annotation analysis. We ...

journal_title：Neurobiology of aging

authors： Ferrari R,Grassi M,Salvi E,Borroni B,Palluzzi F,Pepe D,D'Avila F,Padovani A,Archetti S,Rainero I,Rubino E,Pinessi L,Benussi L,Binetti G,Ghidoni R,Galimberti D,Scarpini E,Serpente M,Rossi G,Giaccone G,Tagliavini F

更新日期：2015-10-01 00:00:00

abstract：:Whole-exome sequencing recently identified a homozygous truncating mutation in Synaptojanin 1 (SYNJ1, PARK20), p.Arg258Gln, in 2 independent families with autosomal recessive young-onset parkinsonism with seizures and cognitive decline. This mutation's role in typical Parkinson's disease (PD) is unclear. We sequenced ...

journal_title：Neurobiology of aging

authors： Chen KH,Wu RM,Lin HI,Tai CH,Lin CH

更新日期：2015-10-01 00:00:00

abstract：:The objective of this study was to assess how longitudinal change in the quantity and quality of white matter signal abnormalities (WMSAs) contributes to the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The Mahalanobis distance of WMSA from normal-appearing white matter using T1-, T2-,...

journal_title：Neurobiology of aging

authors： Lindemer ER,Salat DH,Smith EE,Nguyen K,Fischl B,Greve DN,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2015-09-01 00:00:00

abstract：:There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute...

journal_title：Neurobiology of aging

authors： Whittington RA,Virág L,Gratuze M,Petry FR,Noël A,Poitras I,Truchetti G,Marcouiller F,Papon MA,El Khoury N,Wong K,Bretteville A,Morin F,Planel E

更新日期：2015-08-01 00:00:00

abstract：:The study aimed to evaluate the effects of noninvasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer's disease. A comprehensive literature search was performed on noninvasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fou...

journal_title：Neurobiology of aging

authors： Hsu WY,Ku Y,Zanto TP,Gazzaley A

更新日期：2015-08-01 00:00:00

abstract：:We have used structural equation models to explicitly distinguish functional status and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ" for dementia). Our approach is modular and can be directed to other targets. In this analysis, we construct a δ ortholog representing the "cognitive co...

journal_title：Neurobiology of aging

authors： Royall DR,Bishnoi RJ,Palmer RF

更新日期：2015-07-01 00:00:00

abstract：:The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer's disease, the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with the right hippocampus volume. Here,...

journal_title：Neurobiology of aging

authors： Teipel SJ,Grothe MJ,Wittfeld K,Hoffmann W,Hegenscheid K,Völzke H,Homuth G,Grabe HJ

更新日期：2015-06-01 00:00:00

abstract：:The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. We examined the influence of TOMM40 "523" polymorphism on spatial navigation and its brain s...

journal_title：Neurobiology of aging

authors： Laczó J,Andel R,Vyhnalek M,Matoska V,Kaplan V,Nedelska Z,Lerch O,Gazova I,Moffat SD,Hort J

更新日期：2015-06-01 00:00:00

abstract：:We assessed whether polymers of N-acetylglucosamine (GlcNAc) have any pathogenetic role in Alzheimer's disease (AD). First, by using specific dyes, we found deposits of polymers of GlcNAc in sporadic but not in familial AD. We found that neurons and microglia exposed to GlcNAc and uridine diphosphate (UDP)-GlcNAc are ...

journal_title：Neurobiology of aging

authors： Turano E,Busetto G,Marconi S,Guzzo F,Farinazzo A,Commisso M,Bistaffa E,Angiari S,Musumeci S,Sotgiu S,Bonetti B

更新日期：2015-05-01 00:00:00

abstract：:Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutz...

journal_title：Neurobiology of aging

authors： Lukic A,Uphill J,Brown CA,Beck J,Poulter M,Campbell T,Adamson G,Hummerich H,Whitfield J,Ponto C,Zerr I,Lloyd SE,Collinge J,Mead S

更新日期：2015-05-01 00:00:00

abstract：:Long-term dietary supplementation with resveratrol protects against cardiovascular disease, osteoporesis, and metabolic decline. This study determined how long-term dietary resveratrol treatment protects against retinal ganglion cell (RGC) dendrite loss after optic nerve injury and alters the resolution of the unfolde...

journal_title：Neurobiology of aging

authors： Lindsey JD,Duong-Polk KX,Hammond D,Leung CK,Weinreb RN

更新日期：2015-05-01 00:00:00

abstract：:Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, ...

journal_title：Neurobiology of aging

authors： Kannarkat GT,Lee JK,Ramsey CP,Chung J,Chang J,Porter I,Oliver D,Shepherd K,Tansey MG

更新日期：2015-05-01 00:00:00

abstract：:The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also propose...

journal_title：Neurobiology of aging

authors： Braae A,Medway C,Carrasquillo M,Younkin S,Alzheimer's Research UK (ARUK) Consortium.,Kehoe PG,Morgan K

更新日期：2015-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a complex fatal neurodegenerative disease characterized by progressive degeneration and loss of upper motor neurons in the cerebral cortex and lower motor neurons in brainstem and spinal cord. We established the frequencies of mutations in 4 major ALS-associated genes, SOD1, TARD...

journal_title：Neurobiology of aging

authors： Vrabec K,Koritnik B,Leonardis L,Dolenc-Grošelj L,Zidar J,Smith B,Vance C,Shaw C,Rogelj B,Glavač D,Ravnik-Glavač M

更新日期：2015-03-01 00:00:00

abstract：:A large number of gene products that are enriched in the striatum have ill-defined functions, although they may have key roles in age-dependent neurodegenerative diseases affecting the striatum, especially Huntington disease (HD). In the present study, we focused on Abhd11os, (called ABHD11-AS1 in human) which is a pu...

journal_title：Neurobiology of aging

authors： Francelle L,Galvan L,Gaillard MC,Petit F,Bernay B,Guillermier M,Bonvento G,Dufour N,Elalouf JM,Hantraye P,Déglon N,de Chaldée M,Brouillet E

更新日期：2015-03-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity was localized to the N-terminal res...

journal_title：Neurobiology of aging

authors： Ou-Yang MH,Xu F,Liao MC,Davis J,Robinson JK,Van Nostrand WE

更新日期：2015-02-01 00:00:00

abstract：:An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

journal_title：Neurobiology of aging

authors： Solé M,Miñano-Molina AJ,Unzeta M

更新日期：2015-02-01 00:00:00

abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease have not yet been clarified, and it is not known whether there is a critical period. Estrogen induced significant protection against 6-hydroxydopamine-induced dopaminergic degeneration when administered immediately or 6 weeks, but not 20...

journal_title：Neurobiology of aging

authors： Rodriguez-Perez AI,Borrajo A,Valenzuela R,Lanciego JL,Labandeira-Garcia JL

更新日期：2015-02-01 00:00:00

abstract：:The G4C2 hexanucleotide repeat expansion, located in the first intron of the C9ORF72 gene, represents a major genetic hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Several hypotheses have been proposed on how the transcribed repeat RNA leads to the development of amyotrophic lateral ...

journal_title：Neurobiology of aging

authors： Šket P,Pohleven J,Kovanda A,Štalekar M,Župunski V,Zalar M,Plavec J,Rogelj B

更新日期：2015-02-01 00:00:00

abstract：:Somatostatin (SOM) cortical levels decline in Alzheimer's disease (AD) in correlation with cognitive impairment severity, the latter being closely related to the presence of neurofibrillary tangles. Impaired olfaction is another hallmark of AD tightly related to tau pathology in the olfactory pathways. Recent studies ...

journal_title：Neurobiology of aging

authors： Martel G,Simon A,Nocera S,Kalainathan S,Pidoux L,Blum D,Leclère-Turbant S,Diaz J,Geny D,Moyse E,Videau C,Buée L,Epelbaum J,Viollet C

更新日期：2015-02-01 00:00:00

abstract：:In amyotrophic lateral sclerosis (ALS), objective biomarkers are needed for early diagnosis and progression monitoring. Reduced phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) has recently been proposed to provide such a biomarker in ALS. Here, we aimed to scrutinize this notion, evaluating both p-tau and tota...

journal_title：Neurobiology of aging

authors： Wilke C,Deuschle C,Rattay TW,Maetzler W,Synofzik M

更新日期：2015-02-01 00:00:00

abstract：:Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons...

journal_title：Neurobiology of aging

authors： Das MM,Svendsen CN

更新日期：2015-02-01 00:00:00

abstract：:Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We invest...

journal_title：Neurobiology of aging

authors： Nedelska Z,Ferman TJ,Boeve BF,Przybelski SA,Lesnick TG,Murray ME,Gunter JL,Senjem ML,Vemuri P,Smith GE,Geda YE,Graff-Radford J,Knopman DS,Petersen RC,Parisi JE,Dickson DW,Jack CR Jr,Kantarci K

更新日期：2015-01-01 00:00:00

abstract：:Posterior cingulate cortex (PCC) accumulates amyloid-β (Aβ) early in Alzheimer's disease (AD). The relative concentrations of full-length Aβ and truncated, pyroglutamate-modified Aβ (NpE3) forms, and their correlations to cognitive dysfunction in AD, are unknown. We quantified AβNpE3-42, AβNpE3-40, Aβ1-42, and Aβ1-40 ...

journal_title：Neurobiology of aging

authors： Pivtoraiko VN,Abrahamson EE,Leurgans SE,DeKosky ST,Mufson EJ,Ikonomovic MD

更新日期：2015-01-01 00:00:00

abstract：:Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

journal_title：Neurobiology of aging

authors： Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

更新日期：2015-01-01 00:00:00

abstract：:In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The aim of this study was to identify a particular immune profile in the peripheral blood (PB) and cerebrospinal fluid (CSF) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and its potential...

journal_title：Neurobiology of aging

authors： Lueg G,Gross CC,Lohmann H,Johnen A,Kemmling A,Deppe M,Groger J,Minnerup J,Wiendl H,Meuth SG,Duning T

更新日期：2015-01-01 00:00:00

abstract：:Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct ...

journal_title：Neurobiology of aging

authors： Madsen SK,Gutman BA,Joshi SH,Toga AW,Jack CR Jr,Weiner MW,Thompson PM,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2015-01-01 00:00:00

abstract：:Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated ...

journal_title：Neurobiology of aging

authors： Lythgoe C,Perkes A,Peterson M,Schmutz C,Leary M,Ebbert MT,Ridge PG,Norton MC,Tschanz JT,Munger RG,Corcoran CD,Kauwe JS

更新日期：2015-01-01 00:00:00

abstract：:To characterize the mechanisms underlying region- and age-dependent hippocampal synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing the Swedish-Indiana APP mutation. In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area bu...

journal_title：Neurobiology of aging

authors： Tozzi A,Sclip A,Tantucci M,de Iure A,Ghiglieri V,Costa C,Di Filippo M,Borsello T,Calabresi P

更新日期：2015-01-01 00:00:00

abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

journal_title：Neurobiology of aging

authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

更新日期：2015-01-01 00:00:00

abstract：:Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

journal_title：Neurobiology of aging

authors： Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

更新日期：2015-01-01 00:00:00

abstract：:Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI)-based functional conne...

journal_title：Neurobiology of aging

authors： Das SR,Pluta J,Mancuso L,Kliot D,Yushkevich PA,Wolk DA

更新日期：2015-01-01 00:00:00

abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

journal_title：Neurobiology of aging

authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

更新日期：2015-01-01 00:00:00

abstract：:Previous studies found that polymorphisms rs2736990 and rs356220 in the alpha-synuclein (SNCA) gene increase the risk for Parkinson's disease (PD) in a Caucasian population. In consideration of the overlapping of clinical manifestations and pathologic characteristics among PD, amyotrophic lateral sclerosis (ALS), and ...

journal_title：Neurobiology of aging

authors： Guo XY,Chen YP,Song W,Zhao B,Cao B,Wei QQ,Ou RW,Yang Y,Yuan LX,Shang HF

更新日期：2014-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are adult-onset neurodegenerative diseases with overlapping clinical characteristics. They share common genetic causes and pathologic hallmarks such as TDP-43 neuronal accumulations. Recently, exome analysis identified mutations in matrin...

journal_title：Neurobiology of aging

authors： Millecamps S,De Septenville A,Teyssou E,Daniau M,Camuzat A,Albert M,LeGuern E,Galimberti D,French research network on FTD and FTD-ALS.,Brice A,Marie Y,Le Ber I

更新日期：2014-12-01 00:00:00